A wide variety of immunoassays, reagents, and kits for use in the immunohistochemical staining and analysis of tissue samples. Includes ELISAs, antibodies, tissue crosslinkers, fixatives, permeabilization reagents, molecular probes, dyes, and staining kits.
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BD Horizon - BV480 Rat Anti-Mouse CD45 - CD45 is a transmembrane glycoprotein which is expressed at high levels on cell-surface, and its presence distinguishes leukocytes from non-hematopoietic cells. CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction and the CD45 isoforms detected in the mouse are cell type-, maturation-, and activation state-specific.
CD8 is an antigen coreceptor on T-cell surface which interacts with MHC class I molecules on antigen-presenting cells or epithelial cells. BD Horizon™ BV480 Rat Anti-Mouse CD8a also participates in T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase lck (p56 [lck]).
With its ligand CD70, CD27 acts in a co-stimulatory fashion on T lymphocytes. BD Horizon™ BV480 Mouse Anti-Human CD27 is present on most peripheral blood T lymphocytes and medullary thymocytes and CD27 antigen is upregulated upon activation with the release of a soluble form, 28 to 32 kDa.
HLA-DR antigens are encoded by genes within the Human Leukocyte Antigen (HLA) Complex located on chromosome 6. BD Horizon™ BV480 Mouse Anti-Human HLA-DR is also expressed on activated T cells. This molecule plays a major role in mediating cellular interactions during antigen presentation to CD4-positive T cells.